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Epiberberine (chloride)

CAS No. 889665-86-5

Epiberberine (chloride) ( Epiberberine chloride )

Catalog No. M21543 CAS No. 889665-86-5

Epiberberine chloride is an alkaloid isolated from Coptis chinensis acts as a potent AChE and BChE inhibitor and a non-competitive BACE1 inhibitor (IC50s: 1.07 6.03 and 8.55 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Epiberberine (chloride)
  • Note
    Research use only not for human use.
  • Brief Description
    Epiberberine chloride is an alkaloid isolated from Coptis chinensis acts as a potent AChE and BChE inhibitor and a non-competitive BACE1 inhibitor (IC50s: 1.07 6.03 and 8.55 μM).
  • Description
    Epiberberine chloride is an alkaloid isolated from Coptis chinensis acts as a potent AChE and BChE inhibitor and a non-competitive BACE1 inhibitor (IC50s: 1.07 6.03 and 8.55 μM).
  • Synonyms
    Epiberberine chloride
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    AChE; BChE; BACE1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    889665-86-5
  • Formula Weight
    371.8
  • Molecular Formula
    C20H18ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:7.4 mg/mL (19.9 mM)
  • SMILES
    COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC.[Cl-]
  • Chemical Name
    89-Dimethoxy-1112-dihydro-[13]dioxolo[45-h]isoquinolino[21-b]isoquinolin-13-ium chloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jung HA et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8.
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