Epiberberine (chloride) ( Epiberberine chloride )

Catalog No. M21543 CAS No. 889665-86-5

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HNMR

HPLC

MSDS

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Product Name

Epiberberine (chloride)
Note

Research use only not for human use.
Brief Description

Epiberberine chloride is an alkaloid isolated from Coptis chinensis acts as a potent AChE and BChE inhibitor and a non-competitive BACE1 inhibitor (IC50s: 1.07 6.03 and 8.55 μM).
Description

Epiberberine chloride is an alkaloid isolated from Coptis chinensis acts as a potent AChE and BChE inhibitor and a non-competitive BACE1 inhibitor (IC50s: 1.07 6.03 and 8.55 μM).
Synonyms

Epiberberine chloride
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

AChE; BChE; BACE1
Research Area

——
Indication

——

CAS Number

889665-86-5
Formula Weight

371.8
Molecular Formula

C20H18ClNO4
Purity

>98% (HPLC)
Solubility

DMSO:7.4 mg/mL (19.9 mM)
SMILES

COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC.[Cl-]
Chemical Name

89-Dimethoxy-1112-dihydro-[13]dioxolo[45-h]isoquinolino[21-b]isoquinolin-13-ium chloride

1.Jung HA et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8.

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